Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia
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منابع مشابه
Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia.
Eurycomanone (1) and 13β,21-epoxyeurycomanone (2) were isolated from Eurycoma longifolia for studies of lipolytic activity. Compound 1 enhanced lipolysis in adipocytes with an EC50 of 14.6μM, while its epoxy derivate, compound 2, had a stronger activity with an EC50 of 8.6μM. Based on molecular mechanistic study using several specific inhibitors to lipolytic signaling pathways, it was found tha...
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Eurycoma longifolia has been widely used in traditional herbal preparation and presently there are many commercial products available for general health and libido. However, study on plant breeding of this species is still in its infancy. Thus, Forest Research Institute Malaysia (FRIM) has taken an initiative to conduct provenance trial of this species in order to select the best provenance and...
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آنزیم تریپسین در شرایط قلیایی ناپایدار می باشد .و فعالیت پروتئولیتیکی تریپسین منجربه خود هضمی آن در جایگاههای خاصی می گردد. بنابر این آنزیمی با ناپایداری بالا محسوب میگردد. در سالهای اخیر موفق شدند که با ایجاد تغیرات شیمیایی با اضافه کردن فلزات خاص ، کلسیم و یا عمل استیلاسیون منجر به افزایش پایداری آنزیم تریپسین گردند. مطالعات در حال حاضر نشان می دهد که تریپسین استیله شده فعالیت آنزیمی خود را ...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2017
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2017.07.032